Perineural invasion

In pathology, perineural invasion, abbreviated PNI, refers to cancer spreading to the space surrounding a nerve.

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Significance

Cancers with PNI usually have a poorer prognosis,[1] as PNI is thought to be indicative of perineural spread, which can make resection of malignant lesions more difficult.

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References

  1. ^ Potter, SR.; Partin, AW. (2000). "The significance of perineural invasion found on needle biopsy of the prostate: implications for definitive therapy.". Rev Urol 2 (2): 87–90. PMID 16985741. 

See also